Abstract: As an important innovation subject in the regional innovation system, enterprises have an important impact on promoting regional innovation output. Using Chinese provincial panel data from 2012 to 2018, this paper empirically investigates the promotion of enterprise research and development investment to regional innovation output by introducing two important variables, i.e., industry-university-research collaborative and openness. The results show that there is a positive and significant effect of enterprise research and development investment on regional innovation output. Enterprise research and development investment promotes industry-university-research cooperation development which plays a partial mediating role between enterprise research and development and regional innovation output. The degree of openness plays a positive moderating role between enterprise research and development and university-industry research cooperation development. The research findings have important theoretical and practical implications for promoting regional innovation development.

Key words: regional innovation output, enterprise research and development, industry-university-research cooperation innovation, openness

摘要： 企业作为区域创新系统中的重要创新主体，对促进区域创新产出具有重要影响。利用2012~2018年中国省级面板数据，引入产学研协同发展和对外开放度两个重要变量，实证研究了企业研发投入如何促进区域创新产出的问题，结果表明：企业研发投入对区域创新产出存在正向显著影响；企业研发投入会促进产学研协同发展水平的提升，且产学研协同发展在企业研发投入与区域创新产出间存在部分中介作用；对外开放度在企业研发投入与产学研协同发展间起到正向调节作用，研究结论为推动区域创新发展具有重要的理论和现实意义。

关键词: 区域创新产出, 企业研发投入, 产学研协同发展, 对外开放度