Based on the coupling coordination degree measurement model, principal component analysis, and the panel threshold regression model, using the panel data of 30 provinces and cities in China from 2013 to 2017, taking the coupling degree of industry, university, and research as the threshold variable, this paper explores the heterogeneous impact of R&D staff input and R&D funding on technology performance by dividing regional R&D investment into R&D personnel input and R&D expenditure. The empirical results show that when the coupling degree of industry, university, and research is used as the threshold variable, there is a significant double threshold effect on the R&D personnel input and the R&D expenditure and a three phases of the scientific and technological performance. There is a positive effect of R&D personnel input on the scientific and technological performance when the threshold value increases. When the coupling degree of industry, university, and research is higher than 0.6135, the R&D personnel input has a significant positive effect on the scientific and technological performance. R&D expenditure does not always positively promote the performance of science and technology. When the coupling degree of industry, university, and research is less than 0.5290, the R&D investment will have a negative effect on the scientific and technological performance. When the regional industry, university, and research coupling coordination degree is higher than 0.5290, the R&D expenditure will have a positive effect on the scientific and technological performance, and the role of R&D personnel in investment in the scientific and technology performance is more significant.